Table 2 Pharmacokinetic parameters of artesunate and dihydroartemisininalone and in combination with LPV/r (n = 16)

t_max (h)

1.00 (1.00, 1.00)

1.00 (0.57, 1.43)

1.09 (0.91, 1.31)

0.317

2.00 (1.57, 2.43)

2.00 (1.57, 2.43)

0.96 (0.74, 1.23)

C_max (ng/mL)

110 (80, 140)

140 (80, 190)

1.59 (1.03, 2.47)

0.056

580 (290, 870)

310 (80, 540)

0.63 (0.38, 1.06)

AUC_0–24h (ng h/mL)

200 (160, 230)

240 (190, 290)

1.52 (1.09, 2.10)

0.034*

2370 (1450, 3290)

990 (390, 1590)

0.51 (0.31, 0.85)

AUC_0–∞ (ng h/mL)

–

–

–

–

2680 (1270, 4080)

1370 (620, 2120)

0.55 (0.33, 0.90)

t_1/2z (h)

–

–

–

–

4.02 (1.52, 6.51)

9.99 (3.43, 16.55)

1.89 (1.00, 3.58)

CL/F (L/h)

–

–

–

–

–

–

–

V_z/F (L/kg)

–

–

–

–

–

–

–

Metabolic ratio

11.78 (7.56, 15.99)

3.27 (1.62, 4.92)

0.23 (0.11, 0.47)

0.001*