Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

Table 2 HbS allelic and genotypic frequency (AT for dbSNP rs334) and genetic association to uncomplicated and severe malaria

Genetic testing	SEV	UM	UIF	UM/UIF	SEV/UIF	CM/UIF	SnC/UIF
	n = 263 (%)	n = 141 (%)	n = 304 (%)	P	P	P	P
	n = 263 (%)	n = 141 (%)	n = 304 (%)	OR (95 % CI)	OR (95 % CI)	OR (95 % CI)	OR (95 % CI)
Allelic	3.7	10.9	15.1	9 × 10⁻²	6 × 10⁻¹¹	9 × 10⁻⁴	3 × 10⁻⁶
Allelic				0.69 (0.45–1.07)	0.22 (0.13–0.36)	0.26 (0.11–0.61)	0.31 (0.17–0.54)
Genotypic^a	1.5	8.5	23.7	7 × 10⁻³	2 × 10⁻¹³	1 × 10⁻⁹	4 × 10⁻⁸
Genotypic^a				0.50 (0.30-0.84)	0.15 (0.09-0.27)	0.11 (0.04-0.28)	0.19 (0.30-0.84)

The numbers for SEV, UM and UIF represent only those with successful genotyping
SEV severe malaria, UM uncomplicated malaria, UIF uninfected, CM cerebral malaria, SnC severe non-cerebral malaria
^aPerformed with the dominant genetic model comparing A/A genotypic frequencies to A/T and T/T frequencies

ISSN: 1475-2875