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Table 2 HbS allelic and genotypic frequency (AT for dbSNP rs334) and genetic association to uncomplicated and severe malaria

From: Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

Genetic testing SEV UM UIF UM/UIF SEV/UIF CM/UIF SnC/UIF
n = 263 (%) n = 141 (%) n = 304 (%) P P P P
OR (95 % CI) OR (95 % CI) OR (95 % CI) OR (95 % CI)
Allelic 3.7 10.9 15.1 9 × 10−2 6 × 10−11 9 × 10−4 3 × 10−6
    0.69 (0.45–1.07) 0.22 (0.13–0.36) 0.26 (0.11–0.61) 0.31 (0.17–0.54)
Genotypica 1.5 8.5 23.7 7 × 10−3 2 × 10−13 1 × 10−9 4 × 10−8
    0.50 (0.30-0.84) 0.15 (0.09-0.27) 0.11 (0.04-0.28) 0.19 (0.30-0.84)
  1. The numbers for SEV, UM and UIF represent only those with successful genotyping
  2. SEV severe malaria, UM uncomplicated malaria, UIF uninfected, CM cerebral malaria, SnC severe non-cerebral malaria
  3. aPerformed with the dominant genetic model comparing A/A genotypic frequencies to A/T and T/T frequencies