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Table 5 Accuracy indices of the RDTs (HRP-2 and pLDH) bands compared with PCR to detect P. falciparum

From: Performance of four HRP-2/pLDH combination rapid diagnostic tests and field microscopy as screening tests for malaria in pregnancy in Indonesia: a cross-sectional study

  Carestart First Response Parascreen SD Bioline
PCR as reference test
TP, FP 12, 16 16, 14 14, 18 14, 16
FN, TN 27, 879 23, 881 25, 887 25, 879
Sensitivity (95 % CI) 30.7 (17.5–47.7) 41.0 (25.9–57.8) 35.8 (21.6–52.8) 35.8 (21.6–52.8)
Specificity (95 % CI) 98.2 (97.0–98.9) 98.4 (97.3–99.1) 97.9 (96.7–98.7) 98.2 (97.0–98.9)
PPV (95 % CI) 42.8 (25.0–62.5) 53.3 (34.6–71.2) 43.7 (26.8–62.1) 46.6 (28.7–65.3)
NPV (95 % CI) 97.0 (95.6–97.9) 97.4 (96.1–98.3) 97.2 (95.8–98.1) 97.2 (95.8–98.1)
LR positive (95 % CI) 17.2 (8.7–33.8) 26.2 (13.8–49.8) 17.8 (9.6–33.1) 20.1 (10.6–38.1)
LR negative (95 % CI) 0.7 (0.44–1.28) 0.59 (0.46–0.78) 0.65 (0.52–0.83) 0.65 (0.52–0.82)
DOR (95 % CI) 24.5 (9.7–61.2) 44.4 (17.8–108.9) 27.3 (11.3–65.6) 30.9 (12.5–75.5)
  1. TP true positive, FP false positive, FN false negative, TN true negative, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, DOR diagnostic odds ratio; include positives for mixed species