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Table 2 Number and percentage of sample population (n = 580) considered seropositive for MSP-1-19 and AMA-1 antigens when applying different cutoff criterion

From: Multiple comparisons analysis of serological data from an area of low Plasmodium falciparum transmission

Assay Antigen Malaria-naïve reference population Finite mixture model
Mean + 3SD Mean + 5SD Mean + 3SD Mean + 5SD
Normal distribution
 ELISA MSP-1 362 (62.4 %) 251 (43.3 %) 66 (11.4 %) 41 (7.1 %)
AMA-1 197 (34.0 %) 81 (14.0 %) 38 (6.6 %) 25 (4.3 %)
 Multiplex MSP-1 126 (21.7 %) 105 (18.1 %) 126 (21.7 %) 105 (18.1 %)
AMA-1 108 (18.6 %) 76 (13.1 %) 90 (15.5 %) 71 (12.2 %)
Lognormal distribution
 ELISA MSP-1 355 (61.2 %) 238 (41.0 %) 15 (2.6 %) 5 (0.9 %)
AMA-1 200 (34.5 %) 87 (15.0 %) 5 (0.9 %) 1 (0.2 %)
 Multiplex MSP-1 130 (22.4 %) 110 (19.0 %) 451 (77.8 %) 403 (69.5 %)
AMA-1 120 (20.7 %) 85 (14.7 %) 468 (80.7 %) 421 (72.6 %)