Fig. 3
From: Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy
Anti-malarial drugs impair the deformability of trophozoite-infected red blood cells. The deformability of purified trophozoite-iRBCs was significantly diminished by treatment with all anti-malarial drugs tested, except tetracycline. Treatment with the novel spiroindolone NITD246 and DHIQ—(+) SJ733 showed the highest transiting pressure required for the iRBCs to squeeze through the microconstrictions of the device. **p < 0.001, ***p < 0.0001