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Table 3 The pattern of combined P. falciparum dhfrdhps haplotypes

From: High-level Plasmodium falciparum sulfadoxine-pyrimethamine resistance with the concomitant occurrence of septuple haplotype in Tanzania

Pfdhps haplotypes Pfdhfr haplotypes Total
Wild-type Double Triple
CNCSI CICNI CIRSI CNRNI CIRNI
Wildtype SAKAA 0 4 0 2 20 26
Single AAKAA 1 3 0 4 16 24
SAEAA 0 0 0 0 4 4
SAKAS 0 0 0 0 1 1
Double SGEAA 0 5 0 0 31 36
AAKAS 0 0 0 0 2 2
Triple SGEGA 0 1 0 0 32 33
AGEAA 2 14 1 10 69 96
Quadruple AGEGA 0 1 0 0 11 12
Total   3 28 1 16 186 234
  1. The overall numbers (absolute) parasite haplotypes on the PfdhfrPfdhps genes in the samples successfully analysed (n = 234). Of all the combined haplotypes, the quintuple CIRNI-SGEAA, sextuple CIRNI-AGEAA, CIRNI-SGEGA were more frequently detected
  2. Bold underline indicates the amino acid changes, while SAKAA and CNCSI represent the wildtype haplotype for Pfdhps and Pfdhfr, respectively