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Table 3 Cytotoxicity of ethanol extract trunk bark of Aspidosperma parvifolium, derived fractions and uleine to Vero and HepG2 cells

From: Aspidosperma species as sources of anti-malarials: uleine is the major anti-malarial indole alkaloid from Aspidosperma parvifolium (Apocynaceae)

Extract/fractions/compounds Vero cells HepG2 cells
CC50 (µg/mL) SI W2 SI 3D7 CC50 (µg/mL) SI W2 SI 3D7
EEAP >500 >15.3 >24.4 >1000 30.5 48.7
EEAPA 299.7 305.8 39.3 74.4 75.9 9.7
EEAPN 449.3 29.9 25.3 251.0 16.7 14.1
Uleine 374.6 499.5 31.5 301.2 407.6 25.3
Chloroquine ND ND Nd 185.0 9250.0 142,307.7
  1. EEAP ethanol extract of Aspidosperma parvifolium trunk bark, EEAPA alkaloid fraction prepared from EEAP, EEAPN neutral fraction prepared from EEAP, SI selectivity index