Aspidosperma species as sources of anti-malarials: uleine is the major anti-malarial indole alkaloid from Aspidosperma parvifolium (Apocynaceae)

Table 3 Cytotoxicity of ethanol extract trunk bark of Aspidosperma parvifolium, derived fractions and uleine to Vero and HepG2 cells

Extract/fractions/compounds	Vero cells			HepG2 cells
Extract/fractions/compounds	CC₅₀ (µg/mL)	SI W2	SI 3D7	CC₅₀ (µg/mL)	SI W2	SI 3D7
EEAP	>500	>15.3	>24.4	>1000	30.5	48.7
EEAPA	299.7	305.8	39.3	74.4	75.9	9.7
EEAPN	449.3	29.9	25.3	251.0	16.7	14.1
Uleine	374.6	499.5	31.5	301.2	407.6	25.3
Chloroquine	ND	ND	Nd	185.0	9250.0	142,307.7

EEAP ethanol extract of Aspidosperma parvifolium trunk bark, EEAPA alkaloid fraction prepared from EEAP, EEAPN neutral fraction prepared from EEAP, SI selectivity index

ISSN: 1475-2875