Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania

Malaria Journal

Table 5 Soluble endothelial protein C receptor (sEPCR) levels of hospitalized patients and village population

sEPCR Median [25/75]	Malaria patients 161.1 [124.4/213.4] N = 76		Non-malaria patients 130.6 [109.5/165.5] N = 67		Villages 238.0 [178.0/292.4] N = 71
H1 vs. Hx	150.3 [135.0/200.6] N = 20 P = 0.6	165.6 [123.5/215.0] N = 56	115.6 [108.9/131.8] N = 19 P = 0.09	133.2 [109.8/208.8 N = 48	208 [173.0/247.0] N = 17 P = 0.09	259.0 [196.5/297.5] N = 54
H2 vs. Hx	160.3 [123.9/216.3] N = 66 P = 0.9	163.0 [128.9/195.2] N = 10	126.7 (108.9/154.6] N = 63 P = 0.06	215.3 [191.2/228.6] N = 4	247.0 [178.0/294.0] N = 61 P = 1.0	221.5 [1855.0/276.5] N = 10
H3 vs. Hx	193.2 [169.1/268.0] N = 16 P = 0.009	153.3 [122.6/208.2] N = 60	236.7 [197.6/288.6] N = 13 P < 0.001	119.4 [105.3/139.7] N = 54	493.0 [361.0/628.4] N = 6 P = 0.007	232.0 [178.0/284.5] N = 65
H4 vs. Hx	156.6 [120.6/203.0] N = 10 P = 0.7	161.1 [125.4/213.6] N = 66	131.2 [120.6/169.4] N = 9 P = 0.7	128.7 [109.5/159.6] N = 58	231.3 [194.0/283.0] N = 19 P = 0.8	248.0 [177.8/298.6] N = 52

sEPCR levels were determined in all patients and village samples. Individuals who carry at least one H3 allele had higher levels of sEPCR than those carrying none. This was found in all three groups. Statistically significant differences were found in the general sEPCR level between all three groups. The non-malaria patient group differed from both the malaria and village groups by having lower levels of sEPCR (P = 0.001 and P < 0.001, respectively), and the malaria patient group differed from the village group by having lower levels of sEPCR (P < 0.001). The significance level was set to P < 0.05

ISSN: 1475-2875