Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania

Malaria Journal

Table 6 Haplotype distribution and soluble endothelial protein C receptor (sEPCR) levels in severe and uncomplicated malaria patients

sEPCR Median [25/75]	Severe malaria patients 161.1 [125.2/213.4] N = 52		Uncomplicated malaria patients 157.4 [122.1/212.3] N = 24
H1 vs. Hx	155.9 [128.7/215.6] N = 14 P = 0.9	161.1 [124.8/211.8] N = 38	146.7 [138.5/159.2] N = 6 P = 0.6	172.0 [121.0/226.8] N = 18
H1 (n)	16.4 % (17)		14.6 % (7)
H2 vs. Hx	161.1 [125.5/216.3] N = 46 P = 0.3	145.2 [120.4/183.1] N = 6	146.0 [120.1/212.3] N = 20 P = 0.3	179.1 [155.6/264.8] N = 4
H2 (n)	66.4 % (69)		66.7 % (32)
H3 vs. Hx	217.3 [169.1/318.8] N = 8 P = 0.03	156.5 [123.5/208.4] N = 44	187.4 [165.3/242.5] N = 8 P = 0.1	135.6 [120.1/180.1] N = 16
H3 (n)	7.7 % (8)		16.7 % (8)
H4 vs. Hx	134.1 [119.2/189.2] N = 9 P = 0.3	161.1 [125.6/215.4] N = 43	467.8 [467.8/467.8] N = 1 NA	153.8 [121.6/203.6] N = 23
H4 (n)	9.6 % (10)		2.1 % (1)

The haplotype distribution and sEPCR levels are shown for the severe and uncomplicated malaria patients. A difference in sEPCR level was seen in individuals with at least one H3 allele compared to those with none, however, this was only seen in patients with severe and not uncomplicated malaria. No differences were found in the haplotype distributions or in the general sEPCR level between the two groups. The significance level was set to P < 0.05

ISSN: 1475-2875