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Table 3 Association between antibodies to VAR2CSA with absence of placental malaria in 420 women

From: Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case–control study

 

Increment unit

Unadjusted

Adjusteda

Adjustedb

OR (95 % CI)

p value

OR (95 % CI)

p value

OR (95 % CI)

p value

Immune responses to VAR2CSA

 DBL1 3D7 (Pichia pastoris)

5147.5

0.93 (0.70, 1.22)

0.59

0.90 (0.67, 1.20)

0.47

0.91 (0.68, 1.21)

0.51

 DBL1 7G8 (Pichia pastoris)

5543.8

0.94 (0.70, 1.27)

0.70

0.95 (0.70, 1.28)

0.73

0.95 (0.70, 1.29)

0.75

 DBL1 + 2 FCR3 (Baculovirus)

9077.3

0.85 (0.61, 1.19)

0.35

0.87 (0.62, 1.22)

0.43

0.88 (0.63, 1.23)

0.46

 DBL2 FCR3 (Baculovirus)

2087.0

1.05 (0.89, 1.25)

0.55

1.07 (0.90, 1.27)

0.48

1.08 (0.90, 1.29)

0.40

 DBL3 FCR3 (Baculovirus)

8125.0

1.18 (0.84, 1.67)

0.89

1.22 (0.86, 1.72)

0.27

1.23 (0.87, 1.75)

0.25

 DBL3 7G8 (Pichia pastoris)

11,573.0

1.33 (0.88, 1.99)

0.18

1.28 (0.85, 1.93)

0.24

1.27 (0.85, 1.92)

0.25

 DBL3 FCR3 (Escherichia coli)

9346.8

1.19 (0.82, 1.73)

0.36

1.16 (0.80, 1.68)

0.44

1.15 (0.79, 1.67)

0.46

 DBL4 FCR3 (Baculovirus)

7023.0

1.04 (0.77, 1.41)

0.79

1.06 (0.78, 1.44)

0.73

1.07 (0.78, 1.46)

0.68

 DBL4 7G8 (Pichia pastoris)

5244.3

0.96 (0.73, 1.25)

0.74

0.95 (0.72, 1.24)

0.69

0.94 (0.72, 1.24)

0.68

 DBL4 FCR3/IT4 (Pichia pastoris)

5088.3

0.79 (0.61, 1.01)

0.059

0.80 (0.62, 1.03)

0.080

0.80 (0.63, 1.03)

0.086

 DBL5 FCR3 (Baculovirus)

11,083.0

0.88 (0.59, 1.31)

0.52

0.88 (0.59, 1.32)

0.54

0.87 (0.58, 1.30)

0.49

 DBL5 3D7 (Pichia pastoris)

9502.3

0.72 (0.49, 1.06)

0.098

0.72 (0.49, 1.06)

0.097

0.71 (0.48, 1.04)

0.079

 DBL5 7G8 (Pichia pastoris)

9335.5

0.82 (0.55, 1.21)

0.32

0.81 (0.55, 1.21)

0.31

0.80 (0.54, 1.19)

0.27

 DBL6 FCR3 (Baculovirus)

9534.0

1.11 (0.78, 1.60)

0.56

1.09 (0.76, 1.56)

0.66

1.09 (0.76, 1.56)

0.66

 DBL6 7G8 (Pichia pastoris)

6554.5

1.05 (0.76, 1.46)

0.76

1.08 (0.78, 1.50)

0.66

1.05 (0.76, 1.47)

0.76

 DBL6 FCR3/IT4 (Pichia pastoris)

3803.5

1.08 (0.84, 1.39)

0.56

1.05 (0.82, 1.36)

0.69

1.05 (0.82, 1.35)

0.72

 FV2 FCR3 (Baculovirus)

9579.5

1.06 (0.72, 1.57)

0.77

1.06 (0.71, 1.57)

0.80

1.05 (0.71, 1.57)

0.81

 Per cent high avidity to FV2

1

1.03 (1.01, 1.05)

0.0033

1.03 (1.01, 1.05)

0.0079

1.03 (1.01, 1.04)

0.010

 Per cent of women with ≥35 % high avidity Ab to FV2

1

1.47 (0.92, 2.35)

0.11

1.45 (0.90, 2.32)

0.13

1.43 (0.89, 2.30)

0.15

 Number of domains recognized out of 6

1

0.96 (0.81, 1.14)

0.65

0.96 (0.81, 1.15)

0.67

0.96 (0.81, 1.15)

0.68

 Number of variants recognized out of 15

1

0.99 (0.93, 1.05)

0.67

0.98 (0.92, 1.05)

0.56

0.98 (0.92, 1.05)

0.58

Immune responses to non-pregnancy associated antigens

 CSP

875.5

1.05 (0.86, 0.27)

0.66

1.00 (0.82, 1.22)

1.00

1.01 (0.83, 1.24)

0.93

 RESA

512.5

1.02 (0.94, 1.07)

0.95

1.00 (0.94, 1.06)

0.90

1.00 (0.94, 1.06)

0.90

 AMA-1 3D7

7905.8

0.36 (0.23, 0.56)

<0.0001

0.37 (0.24, 0.58)

<0.0001

0.37 (0.24, 0.57)

<0.0001

 MSP1 3D7

11,844.8

0.62 (0.41, 0.94)

0.025

0.60 (0.39, 0.92)

0.019

0.61 (0.40, 0.94)

0.025

 MSP2 3D7

18,300.8

0.47 (0.29, 0.78)

0.0032

0.47 (0.28, 0.78)

0.0034

0.47 (0.28, 0.78)

0.0038

  1. The antibody levels (MFI) were rescaled by IQR (the difference between 75th and 25th percentiles)
  2. p values that were less than 0.05 were designated in italics
  3. aLogistic regression models were adjusted for gravidity
  4. bLogistic regression models were adjusted for gravidity and age
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Malaria Journal

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