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Table 2 In vitro IC50 values (µM) of compounds 1 and 2

From: Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

Test compounds Sensitive strains Resistant strains RI P value
3D7 D10 K1 Dd2
1 0.064 ± 0.02 0.047 ± 0.01 0.505 ± 0.10 0.463 ± 0.12 10.7 0.343
2 0.041 ± 0.02 0.122 ± 0.03 0.089 ± 0.01 0.076 ± 0.01 2.2 1
Chloroquine 0.019 ± 0.00 0.023 ± 0.00 0.279 ± 0.002 0.180 ± 0.01 14.4 n/a
  1. The values obtained from antiplasmodial tests represent the mean of three independent experiments each performed in triplicate
  2. RI value, values calculated using the highest CQR IC50 value and lowest CQS IC50 value; n/a, not applicable