Analysis of antibody profiles in symptomatic malaria in three sentinel sites of Ivory Coast by using multiplex, fluorescent, magnetic, bead-based serological assay (MAGPIX™)

Table 2 Levels and prevalence of IgG antibody responses in the different sentinel sites

Antibody responses to	Abobo			Korhogo			Man
Antibody responses to	IgG levels^f	%	P^a	IgG levels	%	P^b	IgG levels	%	P^c
Scz_Ag^e	4.1 (1–7.3)	84	NS^d	3.9 (1–10.4)	81	NS	3.6 (1–11)	68	NS
CSP	110 (16–920)	26	<10⁻³	602 (26–2834)	75	<10⁻³	133 (21–2139)	13	NS
LSA1₄₁	376 (22–1475)	61	<0.05	1112 (31–8171)	84	<10⁻³	188 (27–1774)	32	<0.04
LSA3	70 (16–676)	10	NS	143 (40–1035)	31	NS	79 (19–637)	10	NS
SALSA	112 (18–886)	19	<10⁻³	785 (26–7656)	59	<0.004	74 (22–376)	23	NS
AMA1	145 (21–814)	39	<10⁻³	713 (47–3337)	84	<10⁻³	142 (37–747)	35	NS
GLURP	403 (20–2006)	45	NS	1485 (38–7701)	50	NS	344 (29–1440)	35	NS
MSP1p19	1031 (34–2834)	81	NS	2203 (77–9058)	88	NS	946 (42–3305)	68	NS
MSP4p20	817 (22–4231)	77	<0.03	3125 (90–10,674)	97	0.013	831 (49–2455)	74	NS
PF13	351 (21–3820)	45	<10⁻³	1887 (67–10,036)	91	NS	402 (33–1601)	71	NS
CSP P. malariae	60 (24–370)	10	<0.016	232 (33–3202)	38	<0.005	47 (25–267)	6	NS
gSG6 An. gambiae	66 (18–219)	6	NS	126 (25–452)	16	NS	83 (25–744)	3	NS

P Significant differences of prevalence by Fisher exact test
^aAbobo vs Korhogo, ^b Korhogo vs Man, ^cMan vs Abobo, ^d NS non-significant, ^e ELISA measure of antibody responses against schizont extract expressed as mean OD ratio, ^f Mean [minimum–maximum] antibody responses expressed in OD ratio (schizont extract) and MFI

ISSN: 1475-2875