Fig. 1

Signal sequence and domain predictions for PfMDM2 and PfSWIB. Signal sequences and functional domains within a full-length PfMDM2 and b the N-terminus of PfSWIB (first 420 amino acids). The red line indicates a putative mitochondrial localization signal sequence identified by the iPSORT Prediction algorithm with LLRTNIFSA being of critical importance; the blue lines indicate putative nuclear localization sequences identified by cNLS Mapper; the black lines indicate putative nuclear localization signal sequences identified by NucPred; the purple lines indicate the putative SWIB/MDM2 domains as defined on PlasmoDB. The green line represents the truncated form of the recombinant PfMDM2 protein; while the orange line represents the recombinant region expressed for PfSWIB