Table 1 Binding partners for PfMDM2 and PfSWIB identified by biopanning of Plasmodium falciparum phage display libraries
From: Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues
Protein | Identity of the binding partner (total number of amino acids) | Amino acid sequence of binding domain (location in protein) | Annotated domains within binding partner (location in protein) | Region of the binding partner cloned into a His-tag vector |
|---|---|---|---|---|
PfMDM2 | PF3D7_1303400—conserved Plasmodium protein, unknown function (1022) | KKKKKKEQTNEG KKSVKGINKKDK KRNSKVESKK (505–538) | LisH domain (8–34) | 485–664 |
PfSWIB | PF3D7_1356800—serine/threonine protein kinase, putative (ARK3) (4044) | IYEKVNIDNDKV KKKNLHSINDKK IKINKTFMNEKD MKGNNRKKYNTE KRDNIKRNENDN EKK (788–847) | Ser/Thr protein kinase domain, putative (1282–1528) | 601–922 |
PfSWIB | PF3D7_1003600—membrane skeletal protein IMC1-related (ALV5) (281) | PKTIIQEKIIHV PKNVTHIVEK IVEVPEVKYIEK IVEVPHIHYKNK YVPK (58–107) | Inner membrane complex protein domain (58–153) | 2–241 |