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Fig. 1 | Malaria Journal

Fig. 1

From: Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria

Fig. 1

Antigen reactivity of plasma samples from the Ghanaian and Malagasy study population. Plasma samples were collected from 136 Ghanaian and Malagasy volunteers, and the respective reactivity towards the malarial antigens AMA-1 (a), MSP1-19 (b), MSP3 (c) and total 3D7 parasite lysate (d) quantified using standard ELISA towards 50 ng coated antigen each. As negative control, a pool of plasma samples from malaria-naïve European volunteers was used (dashed line). Sample reactivity was quantified after addition of goat anti-human IgG antibody (Thermo Scientific) at a dilution of 1:5000 and subsequent addition of pNPP. The arbitrary units on the y-axis are the sample reactivity divided by the reactivity of the negative control. For statistical analysis of the populations, the non-parametric Kruskal–Wallis and Dunn’s post test was used, asterisks indicate the level of statistical significance

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