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Table 3 Clinical trials of clindamycin plus other drug against P. falciparum malaria

From: Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

Study demographic details Regimen Efficacy (%)
Year Place Reference Pop Nb Clindamycin Other drug Route Days
Dosage Form Nb doses/d Druga Dosage/d Nb doses/d
1974 USA Miller, 1973 [53] A 5        PO 3 100
1975 USA Clyde, 1975 [50] A 5 450 mg Salt 3 Q 560 mg 3 PO 3 60
1975 USA Clyde, 1975 [50] A 2 600 mg Salt 1 Q 560 mg 3 PO 3 50
1975 Thailand Hall, 1975 [79] A 4 450 mg Salt 3 Q 540 mg 3 PO 3 100
1975 Thailand Hall, 1975 [79] A 5 150 mg Salt 3 Q 270 mg 3 PO 3 60
1987 Brazil Kremsner, 1988 [20] A 40 15 mg/kg Base 2 Q 10 mg/kg 2 PO 3 90
1992 Gabon Kremsner, 1994 [52] C 34 5 mg/kg Base 2 Q 12 mg/kg 2 PO 3 88
1993 Gabon Metzger, 1995 [89] C 33 5 mg/kg Base 2 CQ 25 mg/kg 3 PO 3 70
1995 Gabon Kremsner, 1995 [90] C 50 5 mg/kg Base 3 Q 8 mg/kg 3 IV 4 96
1995 Gabon Metzger, 1995 [54] A 40 5 mg/kg Base 2 Q 12 mg/kg 2 PO 3 92
1996 France Parola, 2001 [91] A 53 5 mg/kg Salt 3 Q 8 mg/kg 3 IV 3 100
1997 Gabon Vaillant, 1997 [57] C 161 8 mg/kg Salt 2 Q 8 mg/kg 2 PO 3 97
2000 Thailand Pukrittayakamee [92] A 68 5 mg/kg Base 4 Q 8 mg/kg 3 PO 7 100
2001 Thailand McGready, 2001 [5] P 65 5 mg/kg Salt 3 Q 8 mg/kg 3 PO 7 100
2004 Gabon Bormann, 2004 [6] C 12 10 mg/kg Salt 2 F 60 mg/kg 2 PO 5 100
2004 Gabon Ramharter, 2005 [7] C 100 7 mg/kg Salt 2 A 2 mg/kg 2 PO 3 87
  1. Randomized controlled trial
  2. Only trials with adequate dosing, i.e. clindamycin given at least twice daily are mentioned in this table
  3. Pop population, A adult, C children, P pregnant women
  4. a C chloroquine, Q quinine, F fosmidomycin, A artesunate