Table 1 Efficacy of antimalarial drugs in Angola
Reference | Location | Drug therapy | Follow up | Results (between baseline and follow up) | ||
|---|---|---|---|---|---|---|
Cambournac et al. [8] | Province: Huambo Type of study: efficacy, case-control (placebo), probably partially randomized. Bind to the patient Sampling date: 1953 Participants: 200, mainly < 515 year old. | Pyrimethamine | 24 weeks | All treated subjects were parasite free after the completion of the trial. 5.4 % of the participants in the control group (placebo) carried parasites at endpoint | ||
Suleimanov SD [62] | Province: Type of study: ex vivo survey Sampling date: 1991–1992 Participants: 105 | CQ Fansidar Quinine-tetracycline | Resistance CQ: 61 % showed resistance Fansidar: 40 % showed resistance Quinine-tetracycline: 56 % were successfully cured Quinine-Delayed elimination of the parasites within 7 days of initiation of the therapy | |||
Guthmann et al. [19] | Provinces: Huambo and Bié Type of study: efficacy, partial randomization, with “absence of allocation concealment” Sampling date: 2002–2003 Participants: 619 children (240 Huambo and 379 Bié) | CQ-Huambo AQ-Huambo and Bié SP-Huambo and Bié AQAS-Bié SPAS-Bié | 28 days | Failure rates CQ-84 % AQ-17 % in Huambo and 22 % in Bié SP: 25 % in Huambo and 39 % in Bié AQAS-1.2 % SPAS-1.2 % | Decreased anemia AQ-86 to 45 % SP–85 to 66 % in Huambo and 93 to 66 % in Bié AQAS–83 to 39 % SPAS-90 to 37 % | |
Guthmann et al. [18] | Provinces: Huambo and Bié Type of study: randomized efficacy trial Sampling date: 2004 Participants: 137 children (6–59 months) | AL ASAQ | 28 days | Reinfection AL-3.2 % ASAQ: 6.2 % | Decreased anemia AL: 54 to 13 % ASAQ: 53 to 16 % | Cure rates AL and ASAQ: 100 % |
Kiaco et al. [29] | Province: Luanda Type of study: Interventional prospective cohort Sampling dates: 2011, 2012 and 2013 Participants 103 children and adults (6 months to 56 years; 37 from 2011, 33 from 2012 and 33 from 2013) | AL | 28 days | Adequate clinical and Parasitological response: 90 % Global failure rate (before PCR correction): 9.7 % Samples With pfmdr1 increased copy number + adequate clinical and Parasitological response: 92 % | Cure rate: 91 % | |
Plucinski et al. [23] | Province: Uíge and Zaire Type of study: open-label, nonrandomized Sampling date: 2013 Participants: 320 children (6–108 months) | AL DHA-PPQ | 28 days | Treatment failure AL-7.5 % DHA-PPQ-0.3 % Adequate clinical and parasitological response AL: Zaire-88 % and Uíge-97 % DHA-PPQ: Zaire-100 % and Uíge-100 % | ||