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Table 2 Relationship between antibody levels and age

From: Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas

Burkina Faso

Ghana

Antibody

Antigen

Coefficient (95 % CI)

p value

Adjusted R2

Coefficient (95 % CI)

p value

Adjusted R2

IgG

GLURP R2

6.69 (4.10, 10.91)

<0.0001

0.14

2.82 (0.97, 8.23)

0.057

0.013

MSP1-hybrid

9.28 (4.75, 18.13)

<0.0001

0.11

1.56 (4.10, 5.93)

0.51

0

AS202.11

2.23 (1.33, 4.28)

0.0037

0.021

0.86 (0.35, 2.14)

0.73

0

IgG1

GLURP R2

5.55 (2.91, 10.60)

<0.0001

0.069

3.09 (1.00, 9.61)

0.051

0.014

MSP1-hybrid

2.08 (0.63, 6.83)

0.23

0.0013

0.71 (0.37, 1.36)

0.3

0.0004

IgG2

GLURP R2

10.37 (6.00, 17.94)

<0.0001

0.16

2.39 (0.70, 8.12)

0.16

0.0047

MSP1-hybrid

21.88 (6.98, 68.57)

<0.0001

0.072

1.00 (0.28, 3.66)

1

0

IgG3

GLURP R2

6.16 (4.02, 9.43)

<0.0001

0.16

2.93 (1.20, 7.16)

0.019

0.021

MSP1-hybrid

2.81 (1.85, 4.26)

<0.0001

0.061

3.09 (0.90, 1.06)

0.073

0.011

IgG4

GLURP R2

2.76 (1.62, 4.71)

0.00021

0.036

8.81 (0.94, 82.24)

0.056

0.013

MSP1-hybrid

1.88 (0.96, 3.68)

0.064

0.0069

3.42 (0.62, 18.77)

0.16

0.005

IgM

GLURP R2

36.64 (14.83, 90.52)

<0.0001

0.15

35 (5.01, 248.77)

0.0004

0.054

MSP1-hybrid

8.76 (3.18, 24.12)

<0.0001

0.045

7.62 (1.05, 55.45)

0.045

0.015

AS202.11

3.60 (1.75, 7.41)

0.00055

0.031

6.86 (1.20, 3.93)

0.031

0.018

  1. Coefficient, 95 % confidence level (CI), p values and adjusted R2 values were calculated from univariate linear regression models
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Malaria Journal

ISSN: 1475-2875

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