Table 3 Inhibitory effects (IC₅₀) of compounds on PfPolδ-cat activity and in vitro malaria parasite growth

BuPdGTP

38.0 ± 1.7

85.6 ± 3.7

7-acetoxypentyl-DCBG

55.0 ± 3.4

4.1 ± 0.2

2-amino-4-chloro-6-(3′,4′-dichloroanilino)pyrimidine

104.0 ± 5.6

3.8 ± 0.3

2-amino-4-chloro-6-(3′, 5′-dichloroanilino)pyrimidine

185.0 ± 7.7

34.4 ± 0.4

BuPdGMPPCOP

Inactive^a

173.4 ± 2.7

EtdGTP

Inactive^a

157.8 ± 3.4

HexdGTP

Inactive^a

86.4 ± 0.2

Acyclovir triphosphate

Inactive^a

347.2 ± 8.3

DCBG

Inactive^a

8.8 ± 0.5

N²-(3-fluoro,4-chlorobenzyl)guanine

Inactive^a

7.4 ± 0.3

HB-EMAU

Inactive^a

10.2 ± 0.4