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Table 3 Inhibitory effects (IC50) of compounds on PfPolδ-cat activity and in vitro malaria parasite growth

From: Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ

Compound IC50 (µM)
PfPolδ-cat P. falciparum
BuPdGTP 38.0 ± 1.7 85.6 ± 3.7
7-acetoxypentyl-DCBG 55.0 ± 3.4 4.1 ± 0.2
2-amino-4-chloro-6-(3′,4′-dichloroanilino)pyrimidine 104.0 ± 5.6 3.8 ± 0.3
2-amino-4-chloro-6-(3′, 5′-dichloroanilino)pyrimidine 185.0 ± 7.7 34.4 ± 0.4
BuPdGMPPCOP Inactivea 173.4 ± 2.7
EtdGTP Inactivea 157.8 ± 3.4
HexdGTP Inactivea 86.4 ± 0.2
Acyclovir triphosphate Inactivea 347.2 ± 8.3
DCBG Inactivea 8.8 ± 0.5
N2-(3-fluoro,4-chlorobenzyl)guanine Inactivea 7.4 ± 0.3
HB-EMAU Inactivea 10.2 ± 0.4
  1. a<20 % inhibition at 100 μM