Table 1 In vitro growth of Plasmodium falciparum and inhibitory concentrations of dihydroartemisinin chloroquine, and mefloquine under normo-, hypo- and hyperthermic conditions
Ratio of growth rate | 32 °C | IQR | 37 °C | 41 °C | IQR | |
|---|---|---|---|---|---|---|
Isolate 1 | 1.15 | 1 | 0.16 | |||
Isolate 2 | 0.97 | 1 | 0.48 | |||
DD2 | 0.22 | 1 | 0.04 | |||
3D7 | 0.85 | 1 | 0.07 | |||
7G8 | 0.28 | 1 | 0.09 | |||
Total | 0.85 | 0.25–1.06 | 0.09 | 0.05–0.32 |
50 % inhibitory concentration of anti-malarial drugs (nmol/l and IQR) | ||||||
|---|---|---|---|---|---|---|
CQ 32 °C | CQ 37 °C | DHA 32 °C | DHA 37 °C | MQ 32 °C | MQ 37 °C | |
Isolate 1 | 75.0 (40.2–109.8) | 141.3 (124.9–157.6) | 0.36 (0.30–0.43) | 1.14 (0.96–1.32) | 11.9 (10.2–13.6) | 14.3 (11.7–17.0) |
Isolate 2 | 69.2 (55.7–82.8) | 153.8 (130.1–177.5) | 0.24 (0.17–0.31) | 1.38 (1.19–1.57) | 6.8 (5.1–8.6) | 17.7 (15.9–19.4) |
DD2 | 337.4 (235.0–439.8) | 167.6 (139.3–195.9) | 0.49 (0.36–0.63) | 1.23 (1.05–1.41) | 26.3 (17.0–35.6) | 14.7 (11.3–18.1) |
3D7 | 38.6 (26.8–50.5) | 33.9 (23.1–44.6) | 0.44 (0.32–0.55) | 1.51 (1.37–1.65) | 26.6 (19.9–33.3) | 30.0 (27.0–33.0) |
7G8 | 46.7 (25.8–67.5) | 190.8 (178.4–203.1) | 0.20 (0.16–0.24) | 1.12 (1.03–1.20) | 2.2 (1.9–2.4) | 5.4 (4.4–6.4) |