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Table 1 In vitro growth of Plasmodium falciparum and inhibitory concentrations of dihydroartemisinin chloroquine, and mefloquine under normo-, hypo- and hyperthermic conditions

From: Effect of mild medical hypothermia on in vitro growth of Plasmodium falciparum and the activity of anti-malarial drugs

Ratio of growth rate 32 °C IQR 37 °C 41 °C IQR  
Isolate 1 1.15   1 0.16   
Isolate 2 0.97   1 0.48   
DD2 0.22   1 0.04   
3D7 0.85   1 0.07   
7G8 0.28   1 0.09   
Total 0.85 0.25–1.06   0.09 0.05–0.32  
  50 % inhibitory concentration of anti-malarial drugs (nmol/l and IQR)
CQ 32 °C CQ 37 °C DHA 32 °C DHA 37 °C MQ 32 °C MQ 37 °C
Isolate 1 75.0 (40.2–109.8) 141.3 (124.9–157.6) 0.36 (0.30–0.43) 1.14 (0.96–1.32) 11.9 (10.2–13.6) 14.3 (11.7–17.0)
Isolate 2 69.2 (55.7–82.8) 153.8 (130.1–177.5) 0.24 (0.17–0.31) 1.38 (1.19–1.57) 6.8 (5.1–8.6) 17.7 (15.9–19.4)
DD2 337.4 (235.0–439.8) 167.6 (139.3–195.9) 0.49 (0.36–0.63) 1.23 (1.05–1.41) 26.3 (17.0–35.6) 14.7 (11.3–18.1)
3D7 38.6 (26.8–50.5) 33.9 (23.1–44.6) 0.44 (0.32–0.55) 1.51 (1.37–1.65) 26.6 (19.9–33.3) 30.0 (27.0–33.0)
7G8 46.7 (25.8–67.5) 190.8 (178.4–203.1) 0.20 (0.16–0.24) 1.12 (1.03–1.20) 2.2 (1.9–2.4) 5.4 (4.4–6.4)
  1. IQR interquartile range, 95 % CI 95 % confidence intervals, CQ chloroquine, DHA dihydroartemisinin, MQ mefloquine