Fig. 3

This is a set of brain MRI images of a 5 years old boy who suffered cerebral malaria at the age of 3 years and 3 months. On discharge he had severe neurological sequelae with motor, visual, hearing, and speech deficits and later developed epilepsy. At the time of imaging 20 months later, the visual, speech and motor difficulties had markedly improved but he had developed conduct problems and attention deficit and hyperactivity disorder with violent and aggressive behaviour. The images show generalized widening of sulcal spaces and sylvian fissures in both cerebral hemispheres. There are numerous bilateral T1 W hypointense foci showing confluence in some areas (a); hyper-intense foci in the grey mater and sub cortical regions of the frontal occipital and temporal lobes on T2 W (b and c) and fluid fluid-attenuated inversion recovery (FLAIR) images. There was no restriction of water diffusion on DWI, (d)