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Table 3 Vma subunit knockout strains used in this study

From: Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology

Systematic

Standard

Description

YDL185W

VMA1

Subunit A of the V1 peripheral membrane domain of the vacuolar H+-ATPase

YBR127C

VMA2

Subunit B of V1 peripheral membrane domain of the vacuolar H+-ATPase

YEL027W

VMA3

Proteolipid subunit C of the V0 domain of the vacuolar H+-ATPase

YOR332W

VMA4

Subunit E of the V1 peripheral membrane domain of the vacuolar H+-ATPase

YKL080W

VMA5

Subunit C of the V1 peripheral membrane domain of vacuolar H+-ATPase

YLR447C

VMA6

Subunit D of the V0 integral membrane domain of V-ATPase

YGR020C

VMA7

Subunit F of the V1 peripheral membrane domain of vacuolar H+-ATPase

YEL051W

VMA8

Subunit D of the V1 peripheral membrane domain of vacuolar H+-ATPase

  1. Similar to results for the vma1 strain (see text) PH1 and PH2 expression was found to be synthetically lethal in each yeast strain lacking the designated subunit of yeast vacuolar (H+)-ATPase
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Malaria Journal

ISSN: 1475-2875

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