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Table 3 Titration of the infectivity of PfCSP/Py Spz through the bite(s) of infected mosquitoes

From: A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein

  No. bitesa Infectedb/total mice % patent PPP (days)c
BALB/c mice 1 1/6 17 % 5
5 6/6 100 % 4.2
10 6/6 100 % 3.8
  1. a80 % of An. stephensi mosquito was infected with PfCSP/Py Spz in the salivary gland. Individual salivary glands were examined after each feed to ensure that mice received the indicated number of infected bites
  2. bInfection was defined as the observation of blood stage parasites in thin blood smears by Giemsa staining
  3. cPre-patent period (PPP), number of days after Spz inoculation until detection of blood stage parasites in Giemsa-stained thin blood smears