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Fig. 1 | Malaria Journal

Fig. 1

From: Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

Fig. 1

Inhibitory effects of second-generation antidepressants on primaquine metabolism by recombinant CYP2D6. The relative per cent primaquine remining after 60-min incubations with CYP 2D6 vs antidepressent concentration is shown for each compound tested. Fluoxetine (a) and paroxetine (b) were the most potent inhibitors for CYP2D6-mediated metabolism of primaquine, while desvenlafaxine (h) was the least potent. cg are titration curves for the remaining antidepressants tested (fluvoxamine, sertraline, escitalopram, citalopram, venlafaxine). The determined IC50s are shown above each graph. The error shown is from duplicate experiments

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