Fig. 1

Inhibitory effects of second-generation antidepressants on primaquine metabolism by recombinant CYP2D6. The relative per cent primaquine remining after 60-min incubations with CYP 2D6 vs antidepressent concentration is shown for each compound tested. Fluoxetine (a) and paroxetine (b) were the most potent inhibitors for CYP2D6-mediated metabolism of primaquine, while desvenlafaxine (h) was the least potent. c–g are titration curves for the remaining antidepressants tested (fluvoxamine, sertraline, escitalopram, citalopram, venlafaxine). The determined IC₅₀s are shown above each graph. The error shown is from duplicate experiments