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Fig. 4 | Malaria Journal

Fig. 4

From: Real-time measurement of Plasmodium falciparum-infected erythrocyte cytoadhesion with a quartz crystal microbalance

Fig. 4

Example QCM signals and pictures obtained for CD36. Measurements were carried out on the two-channel sensor platform Fidget Type 1. a The samples (iRBCs and RBCs) were injected after achievement of a stable baseline followed by a short stop-flow interval. Adhesion of iRBCs (FCR3-CD36) led to a decrease of the signal. The low frequency shift obtained with RBCs shows an unspecific drift due to the alterations in the viscosity of the fluid. Frequency shifts after 2.5 h (time frame indicated by vertical dotted lines) are −83 Hz for RBCs and −361 Hz for iRBCs indicating the attachment of iRBCs to CD36 on the quartz; b and c pictures of corresponding quartzes stained with DAPI after measurement in the QCM platform confirming the results. After injection of iRBCs it can be clearly seen in (b) that iRBCs bind to the attached C32 cell membranes expressing CD36 on the quartz. In contrast in (c), after the experiment with RBCs only very few RBCs are detected on the sensor surface and only cell membranes can be seen

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