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Fig. 5 | Malaria Journal

Fig. 5

From: Real-time measurement of Plasmodium falciparum-infected erythrocyte cytoadhesion with a quartz crystal microbalance

Fig. 5

Example QCM signals and pictures obtained for CSA via PLL. Measurements were carried out on the two-channel sensor platform Fidget Type 1. a Example curves show the frequency changes (∆f) during the course of the experiment. After injection of the samples (iRBCs and RBCs), adhesion of iRBCs (FCR3-CSA) led to a decrease of the frequency signal, whereas the frequency signal for RBCs showed no signs of attachment. Frequency shifts after 2.5 h (time frame indicated by vertical dotted lines) are +47 Hz for RBCs and −63 Hz for iRBCs indicating attachment of iRBCs to the CSA; b and c pictures of the corresponding quartzes stained with DAPI after measurement in the QCM platform confirm the results. In b one can see the quartz after the experiment with iRBCs showing the stained nuclei of the attached iRBCs to the CSA on the quartz. In c the quartz after the experiment with RBCs can be seen, showing only very few RBCs on the sensor surface

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