Evaluation of the paediatric dose of chloroquine in the treatment of Plasmodium vivax malaria

Malaria Journal

Table 1 Characteristics: weight, BSA, CQ real-dose, CQ theoretical dose, and blood concentrations of CQ on day 7 of follow-up in each group

Age group (years)	Number records	Weight (kg)	BSA^a (m²)	CQ real dose^b (mg)	CQ theoretical dose^c (m²)	CQD7^d (ng/ml)
5–9	10	21.15 (SD 5.02)	0.83 (SD 0.13)	536.50 (SD 120.69)	717.71 (SD 112.48)	235.47 (SD 69.92)
10–14	14	42.92 (SD 9.02)	1.33 (SD 0.18)	1085.50 (SD 231.58)	1156.80 (SD 156.32)	308.20 (SD 89.69)
15–24	36	61.42 (SD 9.48)	1.68 (SD 0.15)	1542.81 (SD 239.85)	1458.84 (SD 133.87)	342.72 (SD 165.28)
25–34	14	62.12 (SD 12.60)	1.68 (SD 0.20)	1562.29 (SD 322.06)	1460.28 (SD 174.16)	455.35 (SD 137.86)
35–44	11	71.32 (SD 12.94)	1.83 (SD 0.19)	1782.82 (SD 323.69)	1589.72 (SD 162.42)	395.02 (SD 199.02)
45–54	6	64.67 (SD 8.74)	1.74 (SD 0.13)	1604.08 (SD 238.12)	1510.06 (SD 115.54)	384.57 (SD 51.47)
55–65	4	69.75 (SD 13.60)	1.80 (SD 0.21)	1745.00 (SD 342.08)	1564.96 (SD 183.79)	391.20 (SD 94.90)

CQ chloroquine, DCQ desethylchloroquine, SD standard deviation
^aBSA in m² = body surface area calculated using the Boyd formula
BSA (m²) = 0.0003207 × height (cm) 0.3 × weight (g) 0.7285 – [0.0188 × log (weight)]
^bCQ real dose: CQ taken in mg/kg/weight
^cCQ theoretical dose: CQ dose according to: (BSA/1.73)*1500 (adult dose)
^dCQD7: CQ + DCQ on day 7 of follow-up

ISSN: 1475-2875