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Table 2 Effect of trial drug on malaria, by CD4 count at enrolment, ART initiation and at the time of malaria episode

From: Longitudinal effect of CD4 by cotrimoxazole use on malaria incidence among HIV-infected Ugandan adults on antiretroviral therapy: a randomized controlled study

Trial arm Stratum Episodes Person years Rate/100 person years (95 % CI)a Rate ratiob P valuec
CD4 count at ART initiation
 CTX <100 30 698 4.0 (2.8–5.9) 1 0.99
100–249 59 1461 3.9 (3.0–5.1) 1.0 (0.6–1.5)  
250+ 10 229 3.9 (2.0–7.4) 1.0 (0.5–2.0)  
 Placebo <100 92 709 12.4 (9.8–15.7) 1 0.73
100–249 196 1458 13.4 (11.4–15.7) 1.1 (0.8–1.4)  
250+ 36 212 14.7 (10.1–21.5) 1.2 (0.8–1.9)  
CD4 count at enrolment
 CTX <350 14 416 3.5 (2.0–5.9) 1 0.51
350–499 32 900 3.4 (2.4–4.8) 1.0 (0.5–1.9)  
500+ 57 1234 4.3 (3.3–5.7) 1.3 (0.7–2.3)  
 Placebo <350 58 453 13.1 (9.8–17.5) 1 0.98
350–499 117 850 13.6 (11.1–16.7) 1.0 (0.7–1.5)  
500+ 175 1211 13.4 (11.3–16.0) 1.0 (0.7–1.4)  
CD4 count at infection
 CTX <350 21 4618 4.4 (2.9–6.9) 1 0.52
350–499 30 8811 3.3 (2.3–4.7) 0.7 (0.4–1.3)  
500+ 52 1197 4.0 (3.0–5.4) 0.9 (0.5–1.5)  
 Placebo <350 60 390 14.6 (11.1–19.2) 1 0.32
350–499 98 807 11.8 (9.5–14.6) 0.8 (0.6–1.1)  
500+ 192 1317 14.1 (12.0–16.5) 1.0 (0.7–1.3)  
  1. aMarginal means from random effects Poisson regression model with fixed effects for CD4 count stratum, treatment arm and their interaction, and site and year since enrolment
  2. bRate ratio for effect of treatment arm in each CD4 count stratum, adjusted for site and year since enrolment, from random effects Poisson regression model
  3. cP values for overall association of CD4 count with malaria incidence within each treatment arm. P values for interaction between CD4 count and treatment arm: CD4 count at ART initiation P = 0.87; CD4 count at enrolment P = 0.60; CD4 count at infection P = 0.96