Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

Table 2 Summary of immunizations in this study subjects who were true-immunized in 1999–2000) and 2000–2002

	Group
	1999–2000	2000–2001
Number of subjects	3	7

	Median	Range	Median	Range
Infected bites in the first immunization	148	138–334	227	178–252
Total infected bites	1408	1322–1561	1161	1005–1561
Median infected bites per immunization	235	220–260	212	175–260
Number of immunizations	6	6–6	6	5–6
Duration of immunizations (days)	239	231–239	183	175–211
Median immunization interval (days)	37	21–91	29.5	15–100
Interval before CHMI (days)	24	24–24	35.5	15–42
Median gland grade score^a during immunization	3.8	3.8–3.9	3.4	3.2–3.6
Median gland grade score during CHMI	2.4	2.4–2.8	2.8	2.4–3.2

The median and range of the immunizations are shown of all subjects in the two groups (1999–2000 and 2000–2001) who underwent CHMI. Sample sizes were too small to reliably do a statistical comparison
^a Gland score as defined in “Methods” section, salivary infection rates were defined as gland scores: 1–10 sporozoites = gland score 1; 11–100 sporozoites = gland score 2; 101–1000 sporozoites = gland score 3; and >1000 = gland score 4

ISSN: 1475-2875