Fig. 8
Pressure/volume curves are sigmoidal and PMC is decreased in Plasmodium berghei ANKA-infected mice. Wild type and α −/−D animals from infected and control groups were mechanically ventilated and three PV curves were obtained (RR = 6 breaths/min, PEEP = 0 cm H2O, I:E ratio = 4:1, VT = 25–30 mL/kg). The PV curves where peak airway pressure remains stable and near to 20 cm H2O were fitted according to Eq. 1. The curve model gives the pressure value at which the respiratory system has maximum compliance. a Upper (dashdot), mean (solid) and lower (dashed) fitted curves of each group. b The PMC are lower, for infected wild type (P < 0.002) and α −/−D (P < 0.008) mice compared with respective uninfected controls