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Fig. 2 | Malaria Journal

Fig. 2

From: Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi

Fig. 2

Brains from IL-10−/− animals show increased CD11b+ immune cell trafficking and MHC-II upregulation during Plasmodium chabaudi infection. Compiled from multiple independent experiments, cells were isolated from PBS-perfused brains of female IL-10−/− (KO) and C57Bl/6J (WT) mice 7–9 days post-infection (a) Representative FACS plots showing CD11b+CD45hi immune cells in the brain expressing Ly6C and MHC-II. b Total percent and number of Ly6CMHC-II+ tissue macrophages and of Ly6C+MHC-II+ inflammatory monocytes within the CD11b+CD45hi gate. c Histogram and % positive proportion of MHC-II expression and on CD45hiCD11b+ immune cells. Histogram colors Uninfected WT (Grey); day 7 and day 9 post-infection WT (Blue); day 7–9 post-infection IL-10−/− (Red). I infected, U uninfected. Student’s t test *p < 0.05, **p < 0.01, ***p < 0.001

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