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Fig. 4 | Malaria Journal

Fig. 4

From: Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi

Fig. 4

Mice have IFN-γ-producing T cells in the brain during Plasmodium chabaudi infection. Compiled from two independent experiments, cells were isolated from PBS-perfused brains of female IL-10−/− (KO) and C57Bl/6J (WT) mice 7–9 days post-infection. a Representative FACS plots showing CD11bCD45hi immune cells in the brain, gated on the Thy1.2+ population, then CD4 and CD8a. b Total cell numbers of CD4 and CD8 T cells within the CD11bCD45hi/Thy1.2+/CD4+ or CD11bCD45hi/Thy1.2+/CD8+ gate, respectively. c Histograms showing the expression of IFN-y in CD4+ and CD8+ T cells. Right panel MFI of IFN-y-expressing T cells in infected mice and uninfected controls. Percent positive proportion of infected IL-10−/− mice shown. Histogram colors Uninfected IL-10−/− (Grey); day 7 and day 9 post-infection WT (Blue); day 7–9 post-infection IL-10−/− (Red). I infected, U uninfected

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