Table 4 Sensitivity of three RDTs stratified by parasite density (Mbarara and Kazo study sites combined)
Parasite density groups | SD Bioline HRP2 | CareStart HRP2 | CareStart pLDH | SD Bioline HRP2 vs Carestart HRP2 | SD Bioline HRP2 vs CareStart pLDH | CareStart HRP2 vs CareStart pLDH | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | [95 % CI] | % | [95 % CI] | % | [95 % CI] | Diff % | [95 % CI] | Diff % | [95 % CI] | Diff % | [95 % CI] | |
Low (1–1999 parasites/µL) N = 73 | 94.5 | [86.6 to 98.5] | 94.5 | [86.6 to 98.5] | 75.3 | [63.9 to 84.7] | 0.0 | [−5.2 to 5.2] | 19.2 | [8.0 to 30.3]*** | 19.2 | [8.0 to 30.3]*** |
Medium (2000–199,999 parasites/µL) N = 386 | 99.7 | [98.6 to 100] | 99.7 | [98.6 to 100] | 98.7 | [97.0 to 99.6] | 0.0 | [−0.3 to 0.3] | 1.0 | [−0.2 to 2.3] | 1.0 | [−0.2 to 2.3] |
High (200,000 + parasites/µL) N = 59 | 98.3 | [90.9 to 100] | 98.3 | [90.9 to 100] | 98.3 | [90.9 to 100] | 0.0 | [−1.7 to 1.7] | 0.0 | [−1.7 to 1.7] | 0.0 | [−1.7 to 1.7] |
Difference between parasite density groups | ||||||||||||
Low–medium | −5.2 | [−10.5 to 0.0]$$ | −5.2 | [−10.5 to 0.0]$$ | −23.4 | [−33.3 to −13.4]$$$ | ||||||
Low–high | −3.8 | [−10.0 to 2.4] | −3.8 | [−10.0 to 2.4] | −23.0 | [−33.4 to −12.5]$$$ | ||||||
Medium–high | 1.4 | [−1.9 to 4.8] | 1.4 | [−1.9 to 4.8] | 0.4 | [−3.1 to 3.9] | ||||||