Fig. 2
Representative dose response curves for Plasmodium falciparum isolates with severely reduced PPQ sensitivity. PPQ dose–response curves of P. falciparum isolates with a range of susceptibility. a is a PPQ-sensitive isolate (OM-476), while b and c are PPQ-resistant isolates (OM-478, OM-489). % parasite growth was plotted against log [PPQ concentration] using the standard PPQ concentration range from 0 to 674.8 nM (black) and an increased concentration range from 0 to 53,905 nM (blue), with IC50 for each indicated. Filled symbols represent outlier values excluded from curve fitting. Tables present HRP-2 OD values attained for individual isolates at each concentration range, while asterisk indicates values excluded prior to curve fitting