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Fig. 1 | Malaria Journal

Fig. 1

From: A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase

Fig. 1

X-ray crystal structure of the ATP-binding domain of HsNek2 in complex with NCL-00016066 (determined at 2.0 Ǻ). a Chemical structure of NCL-00016066. b X-ray crystal structure of the ATP-binding domain (hinge region of kinase) of human nek2 in complex with NCL-00016066. Indicated is the presence of three predicted hydrogen bonds (arrows) between oxygens (red) and nitrogens (blue) within the hinge region and contained in NCL-00016066. The distances indicated are in angstroms. Also shown is the thioenol ether bond between cysteine 22 in Hsnek-2 and NCL-00016066 (yellow)

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Malaria Journal

ISSN: 1475-2875

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