Day dose administereda | PQ dose (mg/kg) | No hepatic IVIS signalb | No asexual erythrocytic infection (parasitemia)c | No sexual erythrocytic infection (gametocytemia)c |
---|---|---|---|---|
Causal prophylactic model | ||||
D1 | 2.5 | 0/5 (D1), 0/5 (D2) | 0/5 | NA |
5 | 3/5 (D1), 2/5 (D2) | 0/5 | NA | |
10 | 5/5 (D1), 5/5 (D2) | 4/5 | NA | |
20 | 5/5 (D1), 5/5 (D2) | 5/5 | NA | |
D0 | 2.5 | 0/5 (D1), 0/5 (D2) | 0/5 | NA |
5 | 4/5 (D1), 4/5 (D2) | 3/5 | NA | |
10 | 3/5 (D1), 4/5 (D2) | 2/5 | NA | |
20 | 5/5 (D1), 5/5 (D2) | 5/5 | NA | |
D1 | 20 | 0/5 (D1), 0/5 (D2) | 5/5 | NA |
Erythrocytic treatment model | ||||
D4 | 5 | NA | 0/5 | 0/5 |
10 | NA | 0/5 | 0/5 | |
20 | NA | 4/5 | 4/5 |