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Table 1 SNPs of each gene by area

From: Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea)

Codon Mutation Urban area n = 102 N (%) Rural area n = 142 N (%) p value Total prevalence n = 244 N (%) 95% CI
pfdhfr
 pfdhfr N51I 51I 99 (97) 141 (99) 0.174 240 (98) 96.24 to 97.76
 pfdhfr C59R 59R 64 (63) 113 (79) 0.003 177 (72) 66.37 to 77.63
 pfdhfr S108N 108N 101 (99) 142 (100) 0.209 243 (99) 97.75 to 100.25
 pfdhfr I164L 164L 0 2 (1.4) 0.337 2 (0.8) −0.25 to 2.25
pfdhps
 pfdhps S436A 436A 16 (31) 26 (18) 0.592 42 (17) 12.29 to 21.71
 pfdhps A437G 437G 94 (92) 126 (89) 0.375 220 (90) 86.24 to 93.76
 pfdhps K540E 540E 9 (9) 33 (23) 0.003 42 (17) 12.29 to 21.71
 pfdhps A581G 581G 15 (15) 9 (6) 0.039 24 (10) 6.24 to 13.76
pfmdr1
 Pfmdr1 N86Y 86Y 68 (67) 104 (73) 0.266 172 (70) 64.25 to 75.75
 Pfmdr1 D1246Y 1246Y 2 (2) 7 (5) 0.224 9 (4) 1.54 to 6.46
pfcrt
 pfcrt K76T 76T 28 (27) 46 (32) 0.407 74 (30) 24.25 to 35.75
  1. It shows the prevalence of each point of mutation (SNPs) in each gene of P. falciparum studied, in urban and rural settings
  2. ≤0.05 is taken as significance value