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Table 1 Sample MinorityReport output

From: MinorityReport, software for generalized analysis of causal genetic variants

Sample Score Chromosome Genomic mutation Gene mutation Protein mutation Mutant Parent Gene id Strand Protein length Gene description
Mutation counts Mutation proportion Position counts Mutation counts Mutation proportion Position counts
S71 4.7 chr12 G531532A C1267T A423 V 43 0.977 44 12 0.017 693 PF3D7_1211900 1264 Non-SERCA-type Ca2
Transporting P-ATPase (ATP4)
  3.8 chr12 G531566T C1233A P412T 30 1 30 3 0.004 684 PF3D7_1211900 1264 Non-SERCA-type Ca2
Transporting P-ATPase (ATP4)
  3.3 chr6 C1111087A C2890A A964D 31 1 31 3 0.006 522 PF3D7_0627700 + 1147 Transportin
S72 5.5 chr12 A531751T T1048A L350H 89 0.989 90 2 0.003 729 PF3D7_1211900 1264 Non-SERCA-type Ca2
Transporting P-ATPase (ATP4)
S81 3.9 chr12 A531556T T1243A V415D 34 1 34 3 0.005 654 PF3D7_1211900 1264 Non-SERCA-type Ca2
Transporting P-ATPase (ATP4)
s82 6.4 chr12 A531751T T1048A L350H 52 0.981 53 2 0.003 729 PF3D7_1211900 1264 Non-SERCA-type Ca2
Transporting P-ATPase (ATP4)
s83 4.3 chr12 G531566T C1233A P412T 72 0.973 74 3 0.004 684 PF3D7_1211900 1264 Non-SERCA-type Ca2
Transporting P-ATPase (ATP4)
  3.2 chr6 C1111087A C2890A A964D 60 1 60 3 0.006 522 PF3D7_0627700 + 1147 Transportin
  1. MinorityReport output can be combined across multiple strains (s71, s72, s81, s82, s83) derived from the same parent strain in independent resistance experiments. The priority score aids identification of variants that reach near purity in mutant strains relative to the parent strain, with strong supporting evidence. The gene containing a mutation in all strains, here ATPase4, is the known determinant of resistance. Shown are all variants reported when using the default thresholds