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Table 2 Allele frequencies at resistance associated pfdhfr codons 16, 51, 59, 108 and 164

From: Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

Village A16 N51 C59 S108 108N 108S+N I164
Chlorproguanil 36/36 36/36 36/36 21/39 (54%) 17/39 (45%) 1/39 (3%) 39/39
Pyrimethamine 41/41 41/41 41/41 45/46 (98%) 1/46 (2%)a 0 44/44
Chloroquine 31/31 31/31 31/31 21/39 (54%) 18/39 (46%) 0 36/36
Vitamin B 39/39 39/39 39/39 15/45 (33%) 29/45 (65%) 1/45 (2%) 40/40
  1. Resistance associated alleles are shown in italics
  2. aThe frequency of samples with the resistance associated pfdhfr 108N was lower in the pyrimethamine treated village when compared with separate and pooled frequencies from the other villages (P < 0.001)