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Table 2 Allele frequencies at resistance associated pfdhfr codons 16, 51, 59, 108 and 164

From: Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

Village

A16

N51

C59

S108

108N

108S+N

I164

Chlorproguanil

36/36

36/36

36/36

21/39 (54%)

17/39 (45%)

1/39 (3%)

39/39

Pyrimethamine

41/41

41/41

41/41

45/46 (98%)

1/46 (2%)a

0

44/44

Chloroquine

31/31

31/31

31/31

21/39 (54%)

18/39 (46%)

0

36/36

Vitamin B

39/39

39/39

39/39

15/45 (33%)

29/45 (65%)

1/45 (2%)

40/40

  1. Resistance associated alleles are shown in italics
  2. aThe frequency of samples with the resistance associated pfdhfr 108N was lower in the pyrimethamine treated village when compared with separate and pooled frequencies from the other villages (P < 0.001)
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Malaria Journal

ISSN: 1475-2875

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