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Table 2 Hemolysis (%) of normal and G6PD deficient erythrocytes after 2 h incubation with sera from mice dosed with primaquine (15 mg/kg) or PQTZ (100 mg/kg)

From: Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

Erythrocyte samples Hemolysis (%) by time between mouse dosage and serum collection
15 min 30 min 45 min 60 min 120 min
Primaquine
 Normal 0 ± 0 22 ± 12** 32 ± 10** 30 ± 16** 10 ± 11**
 G6PD deficient 0 ± 0 48 ± 2** 54 ± 12** 43 ± 22** 36 ± 13**
PQTZs (4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o and 4p)
 Normal 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0
 G6PD deficient 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0
Not treated
 Normal 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0
 G6PD deficient 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0
  1. Mean and standard deviation of three different animals
  2. ** Statistical differences as compared to not treated controls are indicated by an asterisk (p < 0.05, by Mann–Whitney test)