Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

Malaria Journal

Table 2 Hemolysis (%) of normal and G6PD deficient erythrocytes after 2 h incubation with sera from mice dosed with primaquine (15 mg/kg) or PQTZ (100 mg/kg)

Erythrocyte samples	Hemolysis (%) by time between mouse dosage and serum collection
Erythrocyte samples	15 min	30 min	45 min	60 min	120 min
Primaquine
Normal	0 ± 0	22 ± 12**	32 ± 10**	30 ± 16**	10 ± 11**
G6PD deficient	0 ± 0	48 ± 2**	54 ± 12**	43 ± 22**	36 ± 13**
PQTZs (4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o and 4p)
Normal	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0
G6PD deficient	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0
Not treated
Normal	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0
G6PD deficient	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0 ± 0

Mean and standard deviation of three different animals
** Statistical differences as compared to not treated controls are indicated by an asterisk (p < 0.05, by Mann–Whitney test)

ISSN: 1475-2875