Table 1 Efficacy estimates

Per bite

1

28.42 (28.0–28.9)

22.63 (21.7–23.6)

29.1

25.5

2

70.77 (69.8–71.7)

91.18 (90.7–91.6)

75.0

93.9

3

58.60 (57.5–59.7)

88.58 (88.1–89.1)

62.5

91.2

4

28.37 (27.2–29.5)

34.53 (32.9–36.1)

30.8

40.9

5

5.87 (5.0–6.8)

−4.72 (−6.5 to −3.0)

6.3

−4.0

Per cycle

1

4.80 (3.9–5.7)

−8.78 (−10.6 to −7.0)

6.3

−12.2

2

21.15 (20.3–22.0)

44.88 (43.8–45.9)

22.7

49.4

3

30.20 (29.4–31.1)

28.63 (27.1–30.1)

31.3

35.0

4

32.60 (31.7–33.5)

13.51 (11.7–15.3)

33.3

16.6

Per bite and cycle

1

1

28.42 (27.4–29.5)

4.16 (2.2–6.1)

28.6

1.3

1

2

34.5 (32.0–37.0)

67.30 (65.7–68.9)

50.0

78.0

1

3

75.53 (73.7–77.4)

94.33 (93.7–95.0)

100

100

1

4

97.60 (97.0–98.2)

99.56 (99.3–99.8)

100

100

2

1

99.70 (99.5–99.9)

99.9 (99.8–100)

100

100

2

2

16.14 (13.4–18.9)

60.97 (59.3–62.6)

33.3

71.8

2

3

55.14 (52.6–57.7)

90.18 (89.3–91.0)

66.7

96.9

2

4

88.9 (87.6–90.2)

98.07 (97.7–98.5)

100

100

3

1

97.93 (97.2–98.6)

99.74 (99.6–99.8)

100

100

3

2

25.95 (23.8–28.1)

41.85 (39.8–43.9)

33.3

53.1

3

3

31.60 (29.2–34.0)

44.80 (42.5–47.1)

33.3

57.5

3

4

34.4 (31.7–37.2)

47.7 (45.3–50.2)

50.0

61.6

4

1

38.60 (35.7–41.5)

49.7 (57.0–52.4)

50.0

66.3

4

2

10.65 (8.9–12.4)

33.6 (31.6–35.6)

20.0

44.0

4

3

8.88 (7.0–10.8)

15.18 (12.8–17.5)

0.0

22.1

4

4

8.29 (6.2–10.4)

7.87 (5.3–10.4)

0.0

14.2

5

1

3.23 (0.6–9.5)

4.00 (1.2–6.8)

0.0

9.5

5

2

10.15 (8.6–77.4)

34.9 (33.0–36.9)

20.0

44.1

5

3

8.65 (6.7–10.6)

14.98 (12.5–17.4)

0.0

21.8

5

4

4.12 (1.59–6.7)

5.99 (3.3–8.7)

0.0

11.2