Table 1 The safety of ivermectin at doses higher or more frequent than current approval

Awadzi et al. [100]

75 males with moderate to heavy Onchocerca infection

800 mcg/kg

Single

Single

800 mcg/kg (once)

No difference with controls taking the 150 mcg/kg dose

Awadzi et al. [101]

100 adult males infected with Onchocerca

800 mcg/kg

Days 1 and 4

1.600 mcg/kg (4 days)

No difference with controls taking the 150 mcg/kg dose

Guzzo et al. [62]

68 male and female healthy, adult volunteers

2.000 mcg/kg

Days 1, 4 and 7

3.273 mcg/kg (1 week)

No difference with controls

Kamgno et al. [67]

657 adult males infected with Onchocerca

800 mcg/kg

3-monthly

8.950 mcg/kg (3 years)

The high dose group reported a statistically higher rate of transitory mild and subjective visual side effects

(No structural explanation).

For all other AE comparable rates reported in all groups

Smit et al. [43]

141 adults with uncomplicated malaria

600 mcg/kg

Days 1, 2 and 3

1.800 mcg/kg (3 days)

Pending publication of results