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Fig. 3 | Malaria Journal

Fig. 3

From: Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

Fig. 3

Human kinase profiling of NCGC00114940 and NCGC00100599. 10 µM NCGC00114940 (a) and 10 µM NCGC00100599 (b) were tested against 468 human kinases for binding activities, respectively. NCGC00114940 did not interact with any tested human kinases. NCGC00100599 may interact with 16 human kinases. The top three targets are ABL1 (Q252H)-phosphorylated (9.9% of control), PIK3CD (10% of control), and CDK4-cyclin D3 (15% of control)

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Malaria Journal

ISSN: 1475-2875

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