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Table 2 Spearman correlation of the antibody response to sexual stage antigens with asexual stage antigens and the GMZ2 vaccine antigen of P. falciparum in adults/children from Gabon

From: Recognition of Plasmodium falciparum mature gametocyte-infected erythrocytes by antibodies of semi-immune adults and malaria-exposed children from Gabon

Study participants and vaccination

Antibody against whole asexual stage antigens by C-IFA (Mean PPFC)

Antibody against GMZ2 by ELISA (Mean Ab titers)

 

Rho (95% CI)

Rho (95% CI)

Antibody against stage V gametocytes by C-IFA (Mean PPFC)

Adults

 D0a

0.39 (0.03, 0.66)*

0.17 (−0.18, 0.48)

 D84 (GMZ2)

0.41 (−0.17, 0.78)

0.44 (−0.13, 0.80)

 D84 (Rabies)

0.40 (−0.21, 0.79)

0.54 (−0.03, 0.85)

Children

 D0a

0.16 (−0.24, 0.51)

0.28 (−0.11, 0.60)

 D84 (GMZ2, 30 µg dose)

0.02 (−0.62, 0.64)

−0.10 (−0.69, 0.57)

 D84 (GMZ2, 100 µg dose)

0.06 (−0.59, 0.67)

0.22 (−0.48, 0.75)

 D84 (Rabies)

−0.27 (−0.77, 0.44)

0.22 (−0.48, 0.75)

  1. C-IFA Cytometric immunofluorescence assay, ELISA Enzyme-linked immunosorbent assay, PPFC percent positive fluorescent cells, CI Confidence interval
  2. Significant p value is indicated as follows: * P < 0.05
  3. a D0 Values represent both GMZ2 and Rabies groups together. D0 Day 0, D84 Day 84