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Table 4 Multivariate mixed-effects logistic regression for dhfr and dhps mutations in ANC and delivery samples (pregnant women)

From: Increase in the prevalence of mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates collected from early to late pregnancy in Nanoro, Burkina Faso

Fixed effect(s)

dhfr

dhps

N51

C59

S108

triple dhfr

S436

A437

OR

[95% CI]

p

OR

[95% CI]

p

OR

[95% CI]

p

OR

[95% CI]

p

OR

[95% CI]

p

OR

[95% CI]

p

Age (10 years)

0.29

0.12

0.74

0.010

0.46

0.17

1.29

0.133

0.47

0.16

1.38

0.170

0.39

0.18

0.80

0.010

2.58

0.85

2.94

0.145

0.71

0.29

1.70

0.441

Gravidity

1.25

0.97

1.60

0.087

1.12

0.84

1.50

0.432

1.17

0.85

1.60

0.328

1.16

0.94

1.44

0.165

0.75

0.54

1.06

0.100

1.05

0.81

1.36

0.720

Seasona

1.08

0.68

1.72

0.747

1.07

0.61

1.87

0.805

1.05

0.58

1.90

0.880

1.05

0.69

1.60

0.825

1.58

0.85

2.94

0.145

0.73

0.43

1.22

0.226

IPTp-SP doses

1.09

0.72

1.65

0.672

1.70

0.87

3.34

0.121

2.25

0.94

5.43

0.070

1.04

0.72

1.52

0.819

1.02

0.65

1.60

0.930

1.44

0.81

2.59

0.218

AL

0.64

0.37

1.11

0.109

0.72

0.35

1.47

0.364

0.84

0.38

1.84

0.658

0.67

0.43

1.06

0.090

0.89

0.51

1.55

0.679

0.57

0.33

0.99

0.047

Visitb

0.23

0.03

1.84

0.167

0.09

0.00

1.58

0.099

0.04

0.00

1.39

0.076

0.22

0.03

1.44

0.114

0.25

0.02

2.93

0.267

0.83

0.07

9.42

0.880

SeasonXvisit

4.32

1.31

14.25

0.016

7.56

1.30

43.95

0.024

11.30

1.41

90.44

0.022

4.17

1.51

11.55

0.006

3.00

0.11

85.88

0.520

2.60

0.65

10.44

0.179

 Visitb in high transmission season

1.00

0.16

6.31

0.998

0.66

0.06

7.29

0.736

0.47

0.03

7.56

0.593

0.93

0.17

5.00

0.929

0.38

0.04

3.66

0.401

2.15

0.23

20.41

0.504

 Seasona in Del samples

4.66

1.52

14.27

0.007

8.11

1.50

43.76

0.015

11.83

1.59

87.93

0.016

4.37

1.73

11.07

0.002

2.44

0.70

8.53

0.161

1.88

0.52

6.85

0.337

AgeXvisit

1.00

0.23

4.34

0.995

1.34

0.21

8.36

0.754

1.66

0.20

1343

0.636

0.85

0.22

3.25

0.814

0.44

0.07

2.76

0.378

1.06

0.19

6.11

0.945

 Age in Del samples

0.30

0.08

1.13

0.075

0.62

0.12

3.24

0.567

0.78

0..11

5.28

0.797

0.33

0.11

1.01

0.051

1.10

0.26

4.73

0.898

0.75

0.17

3.41

0.712

GravidityXvisit

1.26

0.79

2.02

0.337

1.26

0.69

2.29

0.455

1.29

0.64

2.58

0.480

1.30

0.85

1.98

0.219

1.33

0.76

2.33

0.319

0.90

0.53

1.53

0.706

 Gravidity in Del samples

1.57

1.02

2.42

0.042

1.41

0.81

2.45

0.221

1.50

0.78

2.91

0.226

1.52

1.06

2.18

0.024

1.00

0.64

1.56

0.995

0.95

0.60

1.50

0.817

  1. Odds ratios (OR) with 95% CI and p values are presented (p values <0.05 in italics)
  2. AL artemether–lumefantrine therapy, Del delivery
  3. aLow transmission season = 0, high transmission season = 1
  4. bANC booking = 0, Delivery = 1; age centred at 25 years
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Malaria Journal

ISSN: 1475-2875

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