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Fig. 1 | Malaria Journal

Fig. 1

From: ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model

Fig. 1

The ICAM-1 receptor and not the CD36 receptor impacts acute stage pathology of Plasmodium chabaudi AS infections. Peripheral blood parasitaemia (a, d) anaemia (b, e) and weight loss (c, f) were compared in serially blood passaged P. chabaudi AS infections of icam-1/− mice (ac), cd36/− mice (df) and their controls. Infections in mice lacking the ICAM-1 receptor resulted in less severe weight loss (day 9, **p < 0.01) and anaemia (day 9, *p < 0.05), yet parasite levels in peripheral blood were higher at this time point (*p < 0.05), compared to infections of wt mice. Infections in cd36−/− animals showed similar anaemia, weight loss and peripheral blood parasitaemia as infections of wt animals throughout the infection (n = 6)

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