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Table 2 Mutations underlie P. yoelii resistance to atovaquone

From: Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

Doses

Isolates

Mutations

Qo2

Qo1

1.44

PyASN1

L271V+K272R

–

 

PyASN2

L271V

–

 

PyASN3

F267L

–

 

PyASN4

F267S

–

 

PyASN5

K272R

–

 

PyASN6

K272R

–

 

PyASN7

K272R

–

 

PyASN8

K272R

–

 

PyASN9

F267L

–

 

PyASN10

K272R

–

1

PyASN11

I258M

–

0.3

PyASN12

F267I

–

 

PyASN13

F267S

–

0.03

PyASN14

–

T139S

 

PyASN15

–

M133I

0.01

PyASN16

–

M133I

  1. Doses were in mg kg−1 BW. Qo1 and Qo2 domains were parts of Qo site of mitochondria cytb gene
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Malaria Journal

ISSN: 1475-2875

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