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Table 3 CYP3A haplotype distribution among pregnant women with uncomplicated Plasmodium falciparum infection in Tanzania

From: Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women

CYP3Ahaplotype

CYP3A SNP combinations

Frequency (%)

CYP3A4*1B

392A>G

CYP3A5 *3

g.6986A>G

CYP3A5 *6

g.14690G>A

CYP3A5 *7

27131_27132insT

GAGA

*1B

wt

Wt

wt

34.2

GAAA

*1B

wt

*6

wt

17.6

GGA

1B

*3

Wt

wt

13.3

AAGA

wt

wt

Wt

wt

11.4

GAGT

*1B

wt

Wt

*7

11.0

AGGA

wt

*3

Wt

wt

8.2

AAAA

wt

wt

*6

wt

3.0

AGGT

wt

wt

Wt

*7

1.3

  1. wt wild type variant allele, SNP single-nucleotide polymorphism