Table 1 Pooled odds ratio of treatment failures and adverse drug reactions after exposure to artemether–lumefantrine and chloroquine among malaria patients in Ethiopia
From: Anti-malarial treatment outcomes in Ethiopia: a systematic review and meta-analysis
| Â | Number of studies | Treatment failure (n/N) | Events/participants (n/N) | Pooled event rate % (95% CI) | I2 (p value) |
|---|---|---|---|---|---|
Overall treatment failures | 21 studies (18–38) | P. falciparum: 373/1868; P. vivax: 114/1255 | 487/3123 | 8.0% (4.0–12.0) | 98.42% (<0.001) |
Treatment failure with P. falciparum patients | 12 studies (21, 23–27, 30–31, 34–38) | AL = 21/1497 | 373/1868 | 7.8% (2.1–13.6) | 99.07% (<0.001) |
Treatment failures in P. vivax patients | 9 studies (18–20, 22, 28–29, 32–35) | CQ = 66/897 CQ–PQ = 1/132 AL = 47/189 | 114/1255 | 7.9% (4.1–11.8) | 88.19% (<0.001) |
Overall ADRs | 7 studies (13, 24, 27, 31, 35, 37, 38) | AL = 501/725 CQ = 75/189 | 344/822 | 39.8% (14.1–65.5) | 99.46% (0.002) |
ADRs to AL | 6 studies (13, 24, 27, 31, 37, 38) | AL = 501/725 | 269/633 | 41.2% (10.1–72.4%) | 99.5% (0.009) |
ADRs to CQ | 2 studies (18, 35) | CQ = 75/189 | 75/189 | 35.6% (5.7%–65.5%) | 95.2% (0.020) |