From: Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles
Parameter | Population estimates (%RSE)b | 95% CIb | IIV [%CV] (%RSE)b | 95% CIb |
---|---|---|---|---|
F | 1 (fixed) | – | 10.7 (42.9) | 4.82–14.1 |
ka (h−1) | 0.317 (3.97) | 0.296–0.343 | – | – |
MTT (h) | 0.496 (17.1) | 0.350–0.679 | 56.1 (36.2) | 31.9–77.4 |
CL/F (l/h) | 9.02 (5.49) | 8.08–10.1 | 23.1 (25.2) | 15.3–27.5 |
VC/F (l) | 115 (4.38) | 106–125 | – | – |
Q/F (l/h) | 16.2 (5.34) | 14.7–18.1 | – | – |
VP/F (l) | 157 (6.59) | 139–178 | 22.8 (36.0) | 13.5–29.9 |
σ | 0.0361 | 0.0263–0.0463 | – | – |
Secondary parametersc | ||||
 Terminal half-life (h) | 25.0 (23.7–29.5) | |||
 AUC0–168 (ng × h/ml) | 1331 (919–1406) | |||
 Cmax (ng/ml) | 45.7 (40.3–46.9) | |||
 Tmax (h) | 4.76 (4.67–5.04) |